3-[(3-Carboxypropyl)carbamoyl]pyridine

Name	Pikamilone
Synonyms	PIKAMILON Pikamilone Pikamiline PikamiloneHCl NICOTINOYL-GABA PIKAMILONE HYDROCHLORIDE 4-(Nicotinamido)butanoic acid 4-nicotinoylamino-butyric acid NICOTINOYL-Γ-AMINOBUTYRIC ACID 4-Nicotinoylamino-butylric acid 3-[(3-Carboxypropyl)carbamoyl]pyridine 4-((Pyridine-3-carbonyl)-amino)-butyric acid 4-[(pyridin-3-ylcarbonyl)amino]butanoic acid 4-((pyridine-3-carbonyl)-amino)-butyric acid sodium 4-[(pyridin-3-ylcarbonyl)amino]butanoate
CAS	34562-97-5
EINECS	1308068-626-2
InChI	InChI=1/C10H12N2O3.Na/c13-9(14)4-2-6-12-10(15)8-3-1-5-11-7-8;/h1,3,5,7H,2,4,6H2,(H,12,15)(H,13,14);/q;+1/p-1

Molecular Formula	C10H12N2O3
Molar Mass	208.21
Density	1.245
Melting Point	211.0 to 215.0 °C
Boling Point	522.4±30.0 °C(Predicted)
Flash Point	269.8°C
Solubility	DMSO (Slightly, Heated), Methanol (Slightly)
Vapor Presure	9.65E-12mmHg at 25°C
Appearance	Solid
Color	White to Off-White
pKa	4.60±0.10(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Use	Used as intelligence improvement medicine

Hazard Symbols	Xi - Irritant
Hazard Class	IRRITANT

toxicological effect	mouse LD50 is 10g kg -1. In the 6-month long-term toxicity test in rats, the daily administration of 3~75mg • kg-1 picomilone showed no abnormal animal behavior and no changes in animal blood, urine and organs. In the 75mg • kg -1 dose group (15 times higher than the therapeutic dose), the morphology of part of the kidney of rats changed. Pathological examination showed that glomerulonephritis and nephrosclerosis occurred, but in clinical trials, long-term or multiple doses of picamyrone No kidney or urinary system diseases occurred. Picamyrone has no sensitizing, carcinogenic and teratogenic effects.
pharmacological action	picamyrone is a brain function improvement drug, which increases cerebral blood flow by strongly expanding cerebral blood vessels. this product has the characteristics of rapid action, long duration, anti-hypoxia, anti-oxidation, etc. At the same time, due to the gamma-aminobutyric acid contained in the molecule, it has a slight sedative effect on the central nervous system, but does not lethargy. The results showed that the administration of picamilone to the twelve fingers had no effect on blood pressure, heart rate, ECG and respiratory system of anesthetized dogs. Picamilon 17.5,35.0,0.5mg kg -1 oral administration had no effect on spontaneous activity, coordinated exercise and sleep rate of mice induced by pentobarbital sodium.
use	as an intelligent improvement medicine

Last Update：2024-04-10 22:29:15

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CAS: 34562-97-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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3-[(3-Carboxypropyl)carbamoyl]pyridine

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